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Advancement in integrin facilitated drug delivery
Daniela Arosio1, Cesare Casagrande2
1Istituto di Scienze e Tecnologie Molecolari (ISTM), CNR, Via C. Golgi 19, I-20133 Milan, Italy.
Advanced Drug Delivery Reviews
|December 22, 2015
Summary
Innovative delivery systems targeting integrins show promise for cancer treatment. Recent advancements focus on novel ligands and nanomedicines for targeted drug delivery, with a need for in vivo validation.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Integrin-targeted anticancer agents have seen advancements in delivery systems like prodrugs and nanoparticles.
- No current integrin-targeted agents have reached clinical development.
- This review focuses on innovative delivery systems developed in the last three years.
Purpose of the Study:
- To survey advancements in integrin-targeted anticancer delivery systems.
- To highlight innovative systems for targeting cancer and endothelial cells.
- To focus on nanomedicine applications for improved biodistribution and intracellular drug release.
Main Methods:
- Review of recent literature (last 3 years) on integrin-targeted delivery systems.
- Analysis of systems utilizing conventional and novel integrin ligands.
- Emphasis on nanomedicine strategies for cancer targeting and drug release.
Main Results:
- Innovative delivery systems exploit integrin ligands for targeting cancer and angiogenesis.
- Nanomedicines aim for preferential biodistribution, uptake, and intracellular release.
- Studies addressing brain tumor delivery and oligonucleotide delivery are highlighted.
Conclusions:
- Advanced delivery systems show potential but require robust in vivo validation.
- Targeting integrins offers a promising avenue for novel cancer therapeutics.
- Oligonucleotide delivery represents a potential third pillar in cancer therapy alongside antibodies and cytotoxics.
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