Related Experiment Video
Updated: Mar 28, 2026
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
31.7K
[General Concept of Drug Delivery System]
Masui. the Japanese Journal of Anesthesiology
|December 23, 2015
Summary
Drug delivery systems (DDS) enhance drug efficacy and reduce side effects by controlling release and improving membrane permeability. Future novel DDS require understanding drug nature and disease, advancing pharmaceutical technology.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Drug delivery systems (DDS) are crucial for optimizing drug efficacy and minimizing adverse effects.
- Controlled-release formulations are key to maintaining therapeutic drug concentrations.
- Enhancing drug permeability across mucosal and skin barriers is vital for transmucosal and transdermal applications.
Purpose of the Study:
- To explore advancements in drug delivery systems.
- To highlight the importance of controlled release and improved permeability.
- To discuss the potential for drug targeting in novel DDS.
Main Methods:
- Review of current drug delivery system strategies.
- Analysis of factors influencing drug release and permeability.
- Consideration of drug targeting approaches.
Main Results:
- Controlled-release mechanisms are essential for maintaining therapeutic drug levels.
- Improved membrane permeability is critical for effective transmucosal and transdermal DDS.
- Drug targeting to lesion sites is an active area of research.
Conclusions:
- Novel DDS with enhanced functionality can be developed through a deeper understanding of drug properties and disease mechanisms.
- Continued progress in pharmaceutical technology is essential for creating superior drug delivery systems.
Related Concept Videos
01:16Drug Delivery: Overview
1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
01:23Oral Drug Delivery Systems: Introduction
209
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
209
01:23Modified-Release Drug Delivery Systems: Classification
250
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
250
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
115
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
115
01:26Oral Drug Delivery Systems: Continuous-Release Systems
208
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
208
01:27Drug Delivery Systems: Different Types
235
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
235