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Design and Optimization of Scored Tablets with Concave Surface and Application of Bayesian Estimation for Solving

Hiroki Katayama1, Yoshiharu Maeda2, Tsubasa Sato3

  • 1Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.

Chemical & Pharmaceutical Bulletin
|November 1, 2021
PubMed
Summary

Developing patient-friendly concavely curved scored tablets (CCST) ensures uniform division for self-medication. This study optimized CCST preparation and used Bayesian estimation to address scale-up challenges, confirming their dividing uniformity advantage.

Keywords:
Bayesian estimationdesign of experimentdividing uniformityfinite element methodscaleup problemscored tablet

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