Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

212
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
212

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vision Impairment, Insurance Coverage, and Out-of-Pocket Spending.

JAMA network open·2026
Same author

Baseline risk factors for the development of open-angle glaucoma in a 12-year glaucoma incidence study: the Thessaloniki Eye Study.

The British journal of ophthalmology·2026
Same author

Associations between obesity, metabolic syndrome and glaucoma in the National Institutes of Health 'All of Us' research programme.

The British journal of ophthalmology·2026
Same author

Geographical barriers to surgical treatment for cataract among California Medicare beneficiaries.

Journal of cataract and refractive surgery·2026
Same author

Cardiovascular Risk and Eye Health: A Cohort Study of the Pooled Cohort Equations and Ocular Disease Incidence.

Ophthalmology·2025
Same author

Strabismus Increases Glaucoma Risk in California Medicare Beneficiaries.

American journal of ophthalmology·2025
Same journal

Access in all areas? A round-up of developments in market access and health technology assessment: part 15.

Journal of comparative effectiveness research·2026
Same journal

Healthcare resource utilization and costs in patients with multiple myeloma administered ciltacabtagene autoleucel in outpatient versus inpatient settings after one to three prior lines of therapy.

Journal of comparative effectiveness research·2026
Same journal

Considerations for assessing the feasibility of network meta-analysis of seasonal vaccines.

Journal of comparative effectiveness research·2026
Same journal

Covariate selection and adjustment for efficacy and safety endpoints in indirect comparative effectiveness analyses of CAR-T-cell therapies for large B-cell lymphoma: a systematic review.

Journal of comparative effectiveness research·2026
Same journal

Acthar Gel treatment in patients with rheumatoid arthritis, systemic lupus erythematosus, or dermatomyositis/polymyositis: analysis of physician-reported charts.

Journal of comparative effectiveness research·2026
Same journal

Use of intracardiac echocardiography and three-dimensional mapping during catheter ablation for atrial fibrillation is associated with reduced complications: a retrospective analysis of United States Medicare Fee-For-Service Database.

Journal of comparative effectiveness research·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

Practice patterns and treatment changes for open-angle glaucoma: the RiGOR study.

Anne L Coleman1,2, Flora C Lum2, Priscilla Velentgas3

  • 1Jules Stein Eye Institute, David Geffen School of Medicine & Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.

Journal of Comparative Effectiveness Research
|December 23, 2015
PubMed
Summary
This summary is machine-generated.

Glaucoma treatment often involves multiple therapies over a year, with prostaglandin analogues, selective laser trabeculoplasty, and trabeculectomy being common interventions. This highlights the complex management of open-angle glaucoma.

Keywords:
comparative effectivenessglaucoma medicationglaucoma surgeryopen-angle glaucomapractice patternsregistrytreatment cascade

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K

Area of Science:

  • Ophthalmology
  • Clinical Research

Background:

  • Open-angle glaucoma management requires diverse therapeutic strategies.
  • Understanding current treatment patterns is crucial for optimizing patient care.

Purpose of the Study:

  • To document the types of glaucoma treatments utilized over a 12-month period.
  • To analyze the frequency of different therapeutic interventions in glaucoma management.

Main Methods:

  • Patients were enrolled upon deciding on laser surgery, incisional surgery, drainage device implantation, or initiating new/additional glaucoma medication.
  • Treatment data was collected over a 12-month period.

Main Results:

  • Prostaglandin analogues were the most frequent medication (60%) for additional therapy.
  • Selective laser trabeculoplasty (87%) and trabeculectomy (57%) were common surgical interventions.
  • A treatment cascade involving multiple therapies occurred in 36% of patients within a year.

Conclusions:

  • Glaucoma treatment frequently involves a sequence of therapies.
  • The study underscores the intricate and multifaceted nature of treating open-angle glaucoma.