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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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The role of protein "Stability patches" in molecular recognition: A case study of the human growth hormone-receptor

Roman Osman1, Mihaly Mezei1, Stanislav Engel2

  • 1Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York.

Journal of Computational Chemistry
|December 23, 2015
PubMed

Keywords:
affinity maturationdesolvationenthalpy-entropy compensationgrowth hormonegrowth hormone receptorhydration layerprotein-protein interactionsolvation energystability patchessteered molecular dynamics simulation

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