Related Experiment Video
Updated: Mar 28, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Recent Advances in the One-Step Synthesis of Distally Fluorinated Ketones
Yuwen Zeng1, Chuanfa Ni1, Jinbo Hu2
1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032, P. R. China.
Abstract:
Fluorinated ketones are intriguing compounds in synthetic chemistry and life science-related fields. The development of efficient methodologies to obtain these compounds is of significant importance and has therefore attracted considerable attention. This Minireview highlights recent progress made in the synthesis of fluorine-containing ketones, with an emphasis on those methods in which the construction of carbonyl groups is synergetic with distal (β-, γ-, δ-, etc.) incorporation of fluorine atoms or fluorinated groups.
Related Concept Videos
Acid-Catalyzed α-Halogenation of Aldehydes and Ketones
In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
Multiple Halogenation of Methyl Ketones: Haloform Reaction
Aldol Condensation with β-Diesters: Knoevenagel Condensation
Ketones with Nonenolizable Aromatic Aldehydes: Claisen–Schmidt Condensation
As the self-condensation of ketones is generally not favored in basic conditions, the self-condensed products do not form in the reaction between ketones and benzaldehyde. The general reaction of Claisen–Schmidt...
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

