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Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies.

Daniela Y Santiesteban1,2, Kelsey Kubelick3,2, Kabir S Dhada1

  • 1Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton, BME Building, 1 University Station, C0800, Austin, TX, 78712, USA.

Annals of Biomedical Engineering
|December 23, 2015
PubMed
Summary

Monitoring/Imaging and Regenerative Agents (MIRAs) can advance tissue engineering and regenerative medicine (TERM) therapies by combining imaging and therapeutic functions. Further research into MIRAs is crucial for clinical translation of TERM treatments.

Keywords:
Imaging contrast agentsIn vivo imagingIn vivo trackingMultimodal trackingReal-time imagingRegenerative medicineScaffold engineeringStem cellsTherapeutic agents

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Tissue engineering and regenerative medicine (TERM) therapies have advanced significantly but face challenges in clinical translation.
  • A key obstacle is the limited understanding of complex tissue engineering processes.
  • In vivo imaging strategies using contrast agents can monitor therapeutic progress.

Purpose of the Study:

  • To highlight the progress of Monitoring/Imaging and Regenerative Agents (MIRAs).
  • To propose future research directions for MIRAs.
  • To facilitate the clinical translation of TERM therapies.

Main Methods:

  • Reviewing current research on MIRAs.
  • Analyzing the dual role of exogenous contrast agents as both imaging and therapeutic agents.
  • Identifying research gaps in MIRA development.

Main Results:

  • MIRAs can potentially improve TERM therapy success by enabling real-time monitoring and therapeutic delivery.
  • Current MIRA research often focuses on imaging or therapeutic applications independently.
  • Significant potential exists for combining diagnostic and therapeutic functions in MIRAs.

Conclusions:

  • Advancing MIRA research is critical for overcoming barriers to TERM clinical translation.
  • MIRAs offer a promising approach to enhance the efficacy and adaptability of TERM treatments.
  • Further investigation into integrated MIRA systems is needed to realize their full potential in regenerative medicine.