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Published on: May 7, 2019
Use of Kidneys with Small Renal Tumors for Transplantation
Alejandro Lugo-Baruqui1, Giselle Guerra2, Adriana Arocha3
1Department of Surgery, Division of Transplantation, Miami Transplant Institute, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Highland Professional Building 1801 N.W. 9th Avenue, Miami, FL, 33136, USA. alejandro.lugo.b@gmail.com.
Abstract:
Population of patients with end-stage renal disease increases every day. There is a vast difference in the number of patients on the waiting list for a kidney transplant, and the number of donors and the gap increases every year. The use of more marginal organs can increase the donor pool. These organs include the kidneys with small renal cell carcinomas (RCTC). There has been a number of reports in the literature about the use of these grafts for renal transplant after tumor excision and reconstruction. These grafts have been reported to be used with good renal function outcomes without an increased risk for malignancy recurrences. We present the collection of evidence for the use of kidneys with RCC for transplantation, technique used for surgical resection, and reconstruction as well as insights on the recommendations for the use of these grafts.
Insights
Kidneys with small renal cell carcinomas (RCTC) can be safely used for transplantation, expanding the donor pool for end-stage renal disease patients. Surgical techniques for tumor removal and reconstruction enable successful outcomes without increasing cancer recurrence risk.
Area of Science:
- Nephrology
- Transplant Surgery
- Oncology
Background:
- Growing end-stage renal disease (ESRD) patient population.
- Significant gap between kidney transplant waiting list numbers and donor availability.
- Need to expand the donor pool using marginal organs.
Purpose of the Study:
- To review evidence on using kidneys with renal cell carcinoma (RCC) for transplantation.
- To describe surgical techniques for tumor excision and reconstruction.
- To provide recommendations for utilizing these grafts.
Main Methods:
- Literature review of studies reporting on kidney transplantation with RCC.
- Analysis of surgical techniques for resection and reconstruction.
- Synthesis of outcomes and recurrence data.
Main Results:
- Kidneys with small RCC can be successfully transplanted after tumor excision and reconstruction.
- Transplanted kidneys demonstrate good renal function.
- No increased risk of malignancy recurrence observed in reported cases.
Conclusions:
- Utilizing kidneys with small RCC is a viable strategy to increase the kidney donor pool.
- Established surgical techniques allow for safe graft preparation.
- Careful patient selection and follow-up are essential for successful outcomes.
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