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Updated: Mar 28, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Orbital presentation of systemic vasculitis: a diagnostic and management challenge
1Department of Ophthalmic Plastic and Reconstructive Surgery Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Background:
Orbital involvement in Wegener's Granulomatosis (WG) is rare and has an overall good prognosis.
Case:
A 60-year-old hypertensive Indian female presented with vision loss and painful proptosis of left eye. Orbital incisional biopsy suggested necrotising small vessel inflammation. The saddle nose deformity and pedal nodulo- ulcerative lesions further consolidated the diagnosis of Wegener's granulomatosis. Systemic immunosuppressant provided remission and the only relapse was managed successfully with intravenous Rituximab.
Conclusion:
Wegener's granulomatosis should be kept in the differential diagnosis of painful proptosis with a diffuse orbital mass in an elderly patient presenting with profound vision loss. Newer immune modulating agents are useful adjuncts in preventing relapses of this fatal disease.
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