[Risk factors for interictal epileptiform discharges on electroencephalogram in children with spastic hemiplegic
Su-Yun Li1, Xu-Guang Qian, Yi-Li Zhao
1Department of Pediatric Neurology, Nanhai Maternity and Children's Hospital, Foshan, Guangdong 528200, China. qianxuguang@163.com.
Insights
Interictal epileptiform discharges (IED) are common in children with spastic hemiplegic cerebral palsy (CP). Brain cortex impairment and low cognitive levels are significant risk factors for IED in this population.
Area of Science:
- Pediatric Neurology
- Neurophysiology
- Developmental Neuroscience
Context:
- Spastic hemiplegic cerebral palsy (CP) is a common childhood neurological disorder.
- Interictal epileptiform discharges (IED) on electroencephalogram (EEG) are frequently observed in children with CP.
- Understanding the prevalence and risk factors of IED is crucial for managing epilepsy in this population.
Purpose:
- To investigate the clinical characteristics of IED on EEG in children with spastic hemiplegic CP.
- To identify risk factors associated with the presence of IED in this cohort.
- To analyze the relationship between IED, epilepsy, and clinical features in spastic hemiplegic CP.
Summary:
- A study of 83 children with spastic hemiplegic CP found that 34% had IED on EEG.
- Epilepsy incidence was significantly higher in children with IED (32%) compared to those without (4%).
- Brain cortex impairment and low cognitive levels were identified as significant risk factors for IED (OR=11.521 and OR=2.238, respectively).
Impact:
- This research highlights the high comorbidity of IED and epilepsy in spastic hemiplegic CP.
- Identifying brain cortex impairment and cognitive level as risk factors aids in targeted screening and intervention.
- Findings contribute to improved clinical management and prognostication for children with CP and IED.
Objective:
To investigate the clinical symptoms and features of interictal epileptiform discharges (IED) on electroencephalogram (EEG) in children with spastic hemiplegic cerebral palsy (CP) and to analyze the risk factors for IED.
Methods:
Eighty-three children with spastic hemiplegic CP were recruited, and their clinical data, results of video-electroencephalogram, imaging findings, and cognitive levels were collected. The influencing factors for IED were determined by multiple logistic regression analysis.
Results:
The incidence of epilepsy was 13% in children with spastic hemiplegic CP; 34% of these cases had IED. The incidence of epilepsy in children with IED (32%) was significantly higher than that in those without IED (4%) (P<0.01). The incidence of IED in children with complications and brain cortex impairment increased significantly (P<0.01). The incidence of IED varied significantly between patients with different cognitive levels (P<0.01). Brain cortex impairment (OR=11.521) and low cognitive level (OR=2.238)were risk factors for IED in children with spastic hemiplegic CP (P<0.05).
Conclusions:
Spastic hemiplegic CP is often found with IED on EEG, and the incidence of epilepsy is higher in children with IED than in those without IED. Brain cortex impairment and low cognitive level have predictive values for IED in children with spastic hemiplegic CP.
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