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Updated: Mar 28, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population
Y M Mishchuk1, S V Serga1, O K Koliada2
1Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
Objective:
To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population.
Materials And Methods:
We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction.
Results:
We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 indi viduals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0.7 %). Genotype distribu tions were not within Hardy Weinberg equilibrium (χ2 = 59,7, p < 0.0001).
Conclusions:
Arg and Pro allele frequencies in the population of Ukraine are 60 and 40 % respectively, which is sig nificantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil.
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