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CYTOKINE IMBALANCE IN PLASMA CELL MYELOMA PATIENTS SURVIVED AFTER THE CHORNOBYL NPP ACCIDENT
1State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
Background:
As is commonly known, cytokines have an ability to influence the inflammatory reactions, cytotoxiceffects, as well as the immune defense of the body. Study of the disease course depending on the ratio of pro andanti inflammatory cytokines is an urgent problem of contemporary oncohematology for the purpose of personalizedtreatment and improvement of the quality of life of patients with plasma cell myeloma who survived after theChornobyl NPP accident.
Objective:
comparative analysis of the state of cytokine regulation in plasma cell myeloma patients at differentstages of therapy depending on a radiation component in the history to optimize the spectrum of clinicalhematological and immunological factors for the prognosis of disease course and assessment of therapy effectiveness.
Materials And Methods:
Content of cytokines (IL6, IL10, TNFα) in peripheral blood was assayed in the stage I-IIIplasma cell myeloma patients (n = 124) by the immunoenzymatic method using horseradish peroxidase as an indicator enzyme. The Multiskan EX 355 enzyme immunoassay analyzer (Termolabsystems, China) with a multichannelvertical scanning spectrophotometer was used.
Results:
A significantly greater violations of cytokine balance and signs of formation of a «cytokine storm» i.e. anexcessive cytokine production were found in the Chornobyl NPP accident survivors, provoking a severe course oftumor process and occurrence of disease complications at all stages of the plasma cell myeloma.
Conclusion:
Study of cytokine imbalance in plasma cell myeloma patients survived after the Chornobyl NPP accident is appropriate to predict the disease clinical course, prevent complications, increase effectiveness and prescribea personalized treatment.
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