Related Experiment Video
Updated: Mar 28, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY DOCUMENTATION OF MACULAR PSEUDOHOLE EVOLUTION AND SPONTANEOUS RESOLUTION
Scott D Walter1, Harry W Flynn
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
Purpose:
To describe the natural history, optical coherence tomography characteristics, and proposed biomechanics of macular pseudohole (MPH) evolution and spontaneous resolution.
Methods:
Clinical case report, with longitudinal follow-up documented by fundus photographs and spectral domain optical coherence tomography.
Results:
A 26-year-old woman presented with visual disturbance secondary to an idiopathic epiretinal membrane. Subsequent formation of an MPH was observed. Spontaneous peeling of the epiretinal membrane occurred in conjunction with posterior vitreous detachment 6.5 years after initial presentation. The MPH resolved, and the patient's vision improved.
Conclusion:
Spontaneous epiretinal membrane peeling represents a potential mechanism for visual and anatomical improvement in eyes with MPH. This is the first published observation of MPH resolution documented by spectral domain optical coherence tomography.
