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Published on: December 14, 2014
Methodological issues associated with preclinical drug development and increased placebo effects in schizophrenia
Matt A Brown1, Ram J Bishnoi1, Sara Dholakia1
1a Department of Psychiatry , University of Texas Health Science Center at San Antonio , San Antonio , TX , USA.
Abstract:
Recent failures to detect efficacy in clinical trials investigating pharmacological treatments for schizophrenia raise concerns regarding the potential contribution of methodological shortcomings to this research. This review provides an examination of two key methodological issues currently suspected of playing a role in hampering schizophrenia drug development; 1) limitations on the translational utility of preclinical development models, and 2) methodological challenges posed by increased placebo effects. Recommendations for strategies to address these methodological issues are addressed.
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