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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Drug Development.

Anna Sladky¹, Jenny Echevarria Medina¹, Patricia Lowe¹

¹USF Health Byrd Alzheimer's Institute, Tampa, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

A mobile clinical trials unit improved Alzheimer's research visibility and participation but faced significant costs and logistical challenges, leading to its retirement. Future use involves transferring the unit to another team.

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Area of Science:

Clinical Trials
Neurodegenerative Diseases
Mobile Health

Background:

Established a mobile clinical trials unit in 2016 to boost Alzheimer's disease clinical trial enrollment in Florida.
Aimed to increase community engagement and access to research opportunities.

Purpose of the Study:

Evaluate the successes and failures of a mobile clinical trials unit.
Analyze financial viability and operational challenges.
Determine the future of the mobile unit.

Main Methods:

Retrospective review of unit operations, including successes and failures.
Analysis of revenue versus expenditures.
Assessment of participant feedback and sponsor interest.

Main Results:

Positive outcomes: Increased community visibility, positive participant feedback, higher appointment requests, and some trial enrollment increases.
Significant challenges: High operational costs (>$100k expenditures vs. $27k revenue), maintenance issues, sponsor hesitancy (especially for monoclonal antibody trials), regulatory hurdles (FDA 1572s), and logistical complexities.
The unit retired due to financial unsustainability and operational barriers, particularly with evolving trial drug types.

Conclusions:

Mobile clinical trials units offer benefits for community outreach and observational studies.
Operational costs, maintenance, and lack of consistent funding/revenue streams pose significant challenges.
The semi-mobile unit was retired due to financial and logistical issues, with plans to transfer it to another institutional team.