Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

125
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
125
Autoimmune Disorders01:29

Autoimmune Disorders

2.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.2K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.7K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K
Rh Blood Group01:19

Rh Blood Group

4.2K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.2K
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

6.0K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-evaluating treatment thresholds in patient blood management: Female patients experience more perioperative anaemia and higher transfusion rates in major elective surgery.

Vox sanguinis·2024
Same author

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression.

Research (Washington, D.C.)·2023
Same author

ONTraC: A 20-Year History of a Successfully Coordinated Provincewide Patient Blood Management Program: Lessons Learned and Goals Achieved.

Anesthesia and analgesia·2022
Same author

A Global Definition of Patient Blood Management.

Anesthesia and analgesia·2022
Same author

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2019
Same author

Hemoglobin Optimization for Coronary Bypass: A 10-Year Canadian Multicenter Experience.

The Annals of thoracic surgery·2018

Related Experiment Video

Updated: Mar 28, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K

Autoimmune Hemolysis: A Journey through Time.

John Freedman1

  • 1Professor Emeritus, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, St Michael's Hospital, Toronto, ON, Canada.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|December 24, 2015
PubMed
Summary

Autoimmune diseases are complex, with over 40 known conditions. Further research is crucial to understand immune dysregulation mechanisms in autoimmune hemolytic anemia (AIHA) for better treatments.

Keywords:
AIHAAutoimmune hemolytic anemiaAutoimmunityBloodHistoryRed blood cells

More Related Videos

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Area of Science:

  • Immunology
  • Pathogenesis of autoimmune diseases

Background:

  • Autoimmune diseases have been recognized for nearly a century.
  • Over 40 human diseases are linked to autoimmune pathogenesis.
  • The precise immune abnormalities defining autoimmune pathogenesis remain unclear.

Purpose of the Study:

  • To investigate the mechanisms of immune dysregulation in Autoimmune Hemolytic Anemia (AIHA).
  • To contribute to the complete elucidation of AIHA pathogenesis.
  • To pave the way for more targeted therapies for difficult-to-treat autoimmune disorders.

Main Methods:

  • This abstract does not specify the methods used.
  • Further research is needed to elucidate the mechanisms.

Main Results:

  • This abstract does not specify the results.
  • Understanding immune dysregulation is key.

Conclusions:

  • Despite extensive knowledge, the exact immune abnormalities in autoimmune pathogenesis require further investigation.
  • Elucidating mechanisms of immune dysregulation in AIHA is essential.
  • Improved understanding may lead to the development of more specific therapies for AIHA.