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Related Concept Videos

Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Resting Potential Decay01:15

Resting Potential Decay

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The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
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Resting Membrane Potential01:24

Resting Membrane Potential

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The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
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Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

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An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
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The Resting Membrane Potential01:21

The Resting Membrane Potential

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Overview
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Action Potential01:14

Action Potential

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Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
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Related Experiment Video

Updated: Mar 28, 2026

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress
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Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress

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Corrigendum: Non-linear leak currents affect mammalian neuron physiology.

Shiwei Huang1, Sungho Hong1, Erik De Schutter1

  • 1Computational Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University Tancha, Japan.

Frontiers in Cellular Neuroscience
|December 24, 2015
PubMed
Summary

This article provides a correction to previously published content. The correction pertains to information on page 432 of volume 9, referencing PMID: 26594148.

Keywords:
Goldman-Hodgkin-Katz equationcerebellar Purkinje neuronsionic concentration-dependencepassive membrane propertiestime constant and input resistance

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Area of Science:

  • Scientific publishing
  • Article corrections
  • Bibliographic accuracy

Context:

  • Correction to a specific published article
  • Volume 9, page 432
  • Associated PMID: 26594148

Purpose:

  • To amend and rectify published scientific literature
  • Ensure accuracy of the scientific record
  • Provide clear reference to the corrected content

Summary:

  • The abstract serves as a corrigendum
  • It identifies the exact location of the error
  • Directs readers to the correct information via PMID

Impact:

  • Maintains the integrity of scientific literature
  • Prevents dissemination of incorrect data
  • Facilitates accurate citation and referencing