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Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
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High efficiency vortex trapping of circulating tumor cells.

Manjima Dhar, Jessica Wong1, Armin Karimi

  • 1Department of Bioengineering, University of California Los Angeles , 420 Westwood Plaza, Los Angeles, California 90095, USA.

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This study introduces an improved Vortex Chip for high-purity isolation of circulating tumor cells (CTCs). The enhanced device captures a wider range of CTC sizes, aiding in personalized cancer therapy.

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Area of Science:

  • Biomedical Engineering
  • Cancer Research
  • Microfluidics

Background:

  • Circulating tumor cells (CTCs) are crucial biomarkers for cancer monitoring and treatment evaluation.
  • Existing CTC isolation technologies often struggle with low purity due to the large background of blood cells.
  • Previous work demonstrated CTC enrichment using the Vortex Chip based on inertial forces in microvortices.

Purpose of the Study:

  • To enhance the Vortex Chip's capability for high-purity isolation of circulating tumor cells (CTCs).
  • To investigate the role of channel geometry in controlling particle capture size.
  • To enable the capture of a wider size range of CTCs for comprehensive analysis.

Main Methods:

  • Utilized microfluidic principles with inertial forces in a Vortex Chip design.
  • Investigated particle entry and stability within microvortices.
  • Modified channel cross-sectional area to influence trapped particle size.
  • Tested the improved device with clinical samples.

Main Results:

  • Discovered that channel cross-sectional area significantly impacts the size of trapped particles.
  • Developed a modified Vortex Chip capable of capturing a broader spectrum of CTC sizes.
  • Demonstrated successful isolation of CTCs from clinical samples with improved purity and size diversity.

Conclusions:

  • The modified Vortex Chip effectively captures a wider range of CTC sizes, revealing greater tumor heterogeneity.
  • This biophysical method offers a promising platform for downstream applications like genetic analysis and cell culture.
  • The technology advances the potential for personalized cancer therapy through improved CTC analysis.