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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Plasma miRNA, an emerging biomarker for pancreatic cancer
Xiazhen Yu1, Michelle R Koenig1, Yuwen Zhu1
11 Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA ; 2 Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, China.
Abstract:
Pancreatic cancer (PC) is one of the most dangerous types of cancer, much due to the lack of clinical symptoms in early stages. Early, noninvasive methods of detecting PC remain a great challenge in clinical practices. MicroRNAs (miRNAs), small and non-coding single-strand RNAs, emerge as potential biomarkers for PC. MiRNAs are involved in PC progression and abnormal level of miRNAs in plasma has been observed in PC patients. A multi-center study recently conducted by Xu and colleagues demonstrated the potential value of using circulating miRNAs to distinguish PC from normal donors and other pancreas-related diseases.
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