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Interleukin (IL)-25: Pleiotropic roles in asthma
Xiujuan Yao1, Yongchang Sun1,2, Wei Wang3
1Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Respirology (Carlton, Vic.)
|December 25, 2015
Summary
Interleukin-25 (IL-25) promotes allergic asthma by driving inflammation and airway remodeling. Targeting IL-25 may benefit specific asthma patient subgroups with high IL-25 levels.
Area of Science:
- Immunology
- Respiratory Medicine
- Cytokine Biology
Background:
- Interleukin-25 (IL-25), a member of the IL-17 cytokine family, enhances T helper type 2 (Th2) immune responses.
- Elevated IL-25 and its receptor (IL-17RB/RA) expression are observed in asthma.
- IL-25 contributes to eosinophilic inflammation, airway hyperresponsiveness (AHR), and airway remodeling in asthma.
Purpose of the Study:
- To review the discovery, cellular origins, and targets of IL-25.
- To update current knowledge on IL-25's role in asthma from animal and human studies.
- To explore the potential of targeting IL-25 for specific asthma phenotypes.
Main Methods:
- Review of experimental and clinical studies on IL-25 in asthma.
- Analysis of IL-25's effects on airway inflammation, AHR, and remodeling.
- Discussion of cellular sources and targets of IL-25 in the asthmatic environment.
Main Results:
- IL-25 induces eosinophilic inflammation, AHR, goblet cell hyperplasia, collagen deposition, and angiogenesis.
- IL-25 appears to play a dominant role in a specific 'IL-25 high' asthma endotype.
- The precise IL-25-producing and responsive cells in asthma require further investigation.
Conclusions:
- IL-25 is a key mediator in certain asthma pathologies.
- Targeting IL-25 or its receptor may offer selective therapeutic benefits for specific asthma patient subgroups.
- Further research is needed to identify IL-25-producing and responsive cells in asthma.
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