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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Contralateral breast dose from partial breast brachytherapy.

R Cole Robinson¹, Christopher L Nelson, Elizabeth S Bloom

¹The University of Texas M.D. Anderson Cancer Center. rcrobins@mdanderson.org.

Journal of Applied Clinical Medical Physics

|December 25, 2015

Summary

This summary is machine-generated.

Accelerated partial breast irradiation (APBI) delivers less radiation dose to the contralateral breast compared to traditional external beam tangents. This study measured doses using thermoluminescent dosimeters during APBI treatment.

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Area of Science:

Oncology
Radiation Oncology
Medical Physics

Background:

Accelerated partial breast irradiation (APBI) is an alternative to whole breast irradiation.
Accurate dose measurement to surrounding tissues is crucial for radiation safety.

Purpose of the Study:

To quantify the radiation dose delivered to the contralateral breast during APBI.
To compare APBI contralateral breast dose with published data for external beam radiotherapy.

Main Methods:

Thermoluminescent dosimeters (TLDs) were used to measure dose on the skin of the contralateral breast.
Dose measurements were taken during APBI simulation, daily quality assurance, and treatment.
Patients received 34 Gy in 10 fractions using a multicatheter device and an Iridium-192 source.

Main Results:

Average contralateral breast doses were 70 cGy for outer quadrant implants and 181 cGy for inner quadrant implants.
These measured doses are lower than those typically reported for external beam breast tangents.

Conclusions:

APBI, particularly with multicatheter devices, results in reduced radiation exposure to the contralateral breast.
These findings support the safety profile of APBI regarding dose to uninvolved breast tissue.