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Decreasing Rates of Neomycin Sensitization in Western Canada

John F Elliott1, Mariam Abbas2, Peter Hull3

  • 1Division of Dermatology, Departments of Medicine & Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada john.elliott@ualberta.ca.

Journal of Cutaneous Medicine and Surgery
|December 25, 2015
PubMed
Abstract

Insights

Neomycin sensitization rates in western Canada have significantly decreased, now mirroring European levels. This decline is linked to reduced availability of neomycin products in Canada.

Area of Science:

  • Dermatology
  • Epidemiology
  • Pharmacology

Background:

  • Neomycin contact sensitization rates in North America (7%-13%) are substantially higher than in Europe (approx. 1.9%).
  • Topical neomycin products have limited availability in Canada.

Purpose of the Study:

  • To investigate the impact of reduced neomycin product availability on sensitization rates in Canada's western provinces.
  • To compare current neomycin sensitization rates in western Canada with historical data and European averages.

Main Methods:

  • A multicenter study analyzed patch test results from 5690 patient charts across four western Canadian universities.
  • Data spanned from 2001-2013 for the University of Saskatchewan and 2009-2013 for the University of Alberta and University of British Columbia.
  • Descriptive statistics, trend analysis, and risk estimates were calculated using SPSS version 20.

Main Results:

  • Neomycin sensitization rates have decreased in western Canada.
  • Current sensitization rates in western Canada are now comparable to those observed in Europe.

Conclusions:

  • The reduced availability of over-the-counter and prescription neomycin products in Canada is the likely driver of decreased sensitization rates.
  • This trend suggests a successful public health intervention through product restriction.
Keywords:
dermatitisdermatologyimmunologyinflammatory dermatoses

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