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Graphene-Based Interfaces Do Not Alter Target Nerve Cells.

Alessandra Fabbro1,2, Denis Scaini1,3,4, Verónica León5

  • 1International School for Advanced Studies (SISSA/ISAS) , Trieste 34136, Italy.

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|December 25, 2015
PubMed
Summary
This summary is machine-generated.

Graphene-based substrates (GBSs) support neuronal growth without altering electrical signaling. These materials are suitable for developing neural prosthetic devices.

Keywords:
graphenehippocampal culturesliquid phase exfoliationneuronal interfacespatch clampsynaptic networks

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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Materials Engineering

Background:

  • Neural interfaces require electrodes that efficiently transfer charge and maintain stability.
  • Electrodes must not alter the physiological properties of brain tissue for safe and effective neural prosthetics.
  • Graphene exhibits promising physico-chemical properties for advanced neuro-interfacing applications.

Purpose of the Study:

  • To investigate the suitability of graphene-based substrates (GBSs) for interfacing with neuronal growth.
  • To assess the impact of GBSs on the functional and synaptic integrity of developing neuronal networks.
  • To determine if GBSs can be used as a base material for neural prosthetic devices.

Main Methods:

  • Culturing brain cells on graphene-based substrates (GBSs).
  • Measuring functional and synaptic integrity of neuronal networks grown on GBSs.
  • Evaluating neuronal signaling properties on uncoated GBSs.

Main Results:

  • Graphene-based substrates (GBSs) support neuronal growth and network formation.
  • Neuronal functional and synaptic integrity remain unaltered on GBSs.
  • GBSs demonstrate permissive interfacing properties without cell adhesion layers.

Conclusions:

  • Graphene-based substrates are suitable for interfacing with neuronal cultures.
  • These substrates maintain normal neuronal signaling, indicating biocompatibility.
  • Graphene offers a promising material for developing carbon-based neural prosthetic devices.