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[Epinephrine's circulatory side effects and intervention instilling through airway]
1Respiratory Medicine, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.
Objective:
Epinephrine instilling through peripheral airway in bronchoscope was recommended by guideline for hemostasis. We explored the mechanism of the circulatory system side effects by epinephrine absorbing through airway and the way to alleviate the epinephrine's circulatory side effects by blending albumin.
Methods:
A total of 15 adult male cats were divided averagely and randomly into three groups. Group albumin+epinephrine, Group epinephrine and Group saline were instilled into bronchia by epinephrine admixed of albumin, saline or saline alone. Invasive blood pressure and heart rate and concentration of epinephrine were recorded before administration, and at points of the 30(th) second, 60(th) second, 90(th) second, 3(rd) minute, 5(th) minute, 10(th) minute, 15(th) minute, 30(th) minute, 60(th) minute, 90(th) minute and 120(th) minute after administration.
Results:
In Group albumin+epinephrine the increased range of systolic blood pressure and heart rate and concentration of epinephrine were 4.75% and 2.72% and 6.67 ng/ml;in Group saline+epinephrine were 13.90% and 11.48% and 8.16 ng/ml;in Group saline systolic blood pressure decreased 12.11% and heart rate and concentration of epinephrine increased 6.87% and 0.37 ng/ml. The tendency of variation of systolic blood pressure and heart rate had statistic difference between Group albumin+epinephrine and Group saline+epinephrine, between Group saline+epinephrine and Group saline. The tendency of variation of concentration of epinephrine had statistic difference among three groups.
Conclusion:
Epinephrine instilling through peripheral airway can cause the circulatory system side effects; blending Albumin can alleviate the epinephrine's circulatory side effects by decreasing the absorption through Airway.
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