Related Experiment Video
Updated: Mar 28, 2026
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss
Nacim Bouheraoua1, Clemence Bonnet1, Antoine Labbé1
1From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
Purpose:
To report long-term results of Artisan phakic intraocular lens (pIOL) to correct myopia and to propose a model predicting endothelial cell loss after pIOL implantation.
Setting:
Quinze-Vingts National Ophthalmology Hospital, Paris, France.
Design:
Retrospective, interventional case series.
Methods:
Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and central endothelial cell count (ECC) were determined before and at yearly intervals up to 5 years after pIOL implantation. Linear model analysis was performed to present a model that describes endothelial cell loss as a linear decrease and an additional decrease depending on postoperative loss.
Results:
A total of 49 patients (68 eyes) implanted with pIOLs from January 2000 to January 2009 were evaluated. The mean preoperative and final spherical equivalent (SE) were -13 ± 4.10 and -0.75 ± 0.74 diopters (D), respectively. The mean preoperative and final central ECC were 2629 ± 366 and 2250 ± 454 cells/mm(2), respectively. There were no intraoperative complications for any of the eyes. One eye required surgery for repositioning the pIOL, and 1 eye required pIOL exchange for postoperative refractive error. The model predicted that for patients with preoperative ECC of 3000, 2500, and 2000 cells/mm(2), a critical ECC of 1500 cells/mm(2) will be reached at 39, 28, and 15 years after implantation, respectively.
Conclusions:
Implantation of the pIOL was an effective and stable procedure after 5 years of follow-up. The presented model predicted EC loss after pIOL implantation, which can assist ophthalmologists in patient selection and follow-up.
Financial Disclosure:
The authors report no conflict of interest.
