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Published on: March 13, 2013
Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
Preeti Yadav1, Hardeep Singh Gill2, Karam Chand3,4
1Department of Chemistry, University of Delhi, Delhi 110007, India. sandesh4preeti@gmail.com.
Abstract:
We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy.
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