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Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
Published on: June 23, 2023
Nutritional modifications in male infertility: a systematic review covering 2 decades
Ladan Giahi1, Shayan Mohammadmoradi2, Aida Javidan2
1L. Giahi is with the Reproductive Biotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research, Tehran, Iran. S. Mohammadmoradi and A. Javidan are with the Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA. M.R. Sadeghi is with the Monoclonal Antibody Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research, Tehran, Iran. l.giahi@avicenna.ac.ir.
Context:
Studies suggest that appropriate nutritional modifications can improve the natural conception rate of infertile couples.
Objectives:
The purpose of this study was to review the human trials that investigated the relation between nutrition and male infertility.
Data Sources:
A comprehensive systematic review of published human studies was carried out by searching scientific databases. Article selection was carried out in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The American Dietetic Association Research Design and Implementation Checklist was also used for quality assessment.
Data Extraction:
A total of 502 articles were identified, of which 23 studies met the inclusion criteria.
Data Synthesis:
Results indicated that a healthy diet improves at least one measure of semen quality, while diets high in lipophilic foods, soy isoflavones, and sweets lower semen quality.
Conclusion:
The role of daily nutrient exposure and dietary quality needs to be highlighted in male infertility. Mechanistic studies addressing the responsible underlying mechanisms of action of dietary modifications are highly warranted.
Systematic Review Registration:
PROSPERO 2013: CRD42013005953. Available at: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42013005953.
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