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Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Spray drying formulation of amorphous solid dispersions.

Abhishek Singh1, Guy Van den Mooter1

  • 1Drug Delivery and Disposition, KU Leuven, Leuven, Belgium.

Advanced Drug Delivery Reviews
|December 27, 2015
PubMed
Summary

Spray drying effectively creates amorphous solid dispersions (ASDs) for poorly water-soluble drugs (PWSDs). This review explores formulation, process variables, and scale-up challenges for optimizing ASD manufacturing.

Keywords:
Amorphous solid dispersionsDownstream processingDrying kineticsElectrosprayingMollier diagramPoorly water soluble drugsScale-upSpray drying

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Area of Science:

  • Pharmaceutical Manufacturing
  • Materials Science

Background:

  • Amorphous solid dispersions (ASDs) enhance the solubility and bioavailability of poorly water-soluble drugs (PWSDs).
  • Spray drying is a key technique for producing ASDs, but its complexity requires careful control of numerous interacting variables.

Purpose of the Study:

  • To provide a comprehensive review of spray drying for ASD formulation.
  • To discuss critical quality attributes (CQAs), formulation and process variables, and downstream processing.
  • To highlight recent advances and future research directions in spray drying techniques for ASDs.

Main Methods:

  • Review of existing literature on spray drying and amorphous solid dispersions.
  • Analysis of formulation and process parameters influencing ASDs.
  • Discussion of instrumentation, thermodynamics, drying kinetics, particle formation, and scale-up.

Main Results:

  • Identified numerous interdependent factors affecting ASD properties during spray drying.
  • Detailed the influence of formulation and process variables on critical quality attributes (CQAs).
  • Outlined challenges and recent advancements in spray drying technology for ASDs.

Conclusions:

  • Spray drying is a versatile method for ASD production, but optimization requires understanding complex interactions.
  • Further research is needed in advanced spray-based drying techniques and scale-up strategies.
  • Effective ASD formulation through spray drying is crucial for improving drug delivery of PWSDs.