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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
Published on: January 26, 2024
TLS in Tumors: What Lies Within
Catherine Sautès-Fridman1, Wolf Herman Fridman1
1INSERM, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; University Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; UPMC University Paris 06, Sorbonne Universités, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France.
Abstract:
The role of tertiary lymphoid structures (TLS) in cancer has recently been illustrated and revisited using mouse models. Joshi et al. describe regulatory T (Treg) cell infiltration and functional heterogeneity of TLS in lung tumors. Finkin et al. report that inflammation-associated TLS serve as niche for tumor progenitor cells, which may lead to recurrence in hepatocellular-carcinoma.
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