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Updated: Mar 28, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Current and future biomarkers in allergic asthma
U M Zissler1, J Esser-von Bieren1, C A Jakwerth1
1Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German Research Center for Environmental Health member of the German Center for Lung Research (DZL), Munich, Germany.
Identifying new biomarkers for allergic rhinitis and asthma is crucial for early diagnosis and treatment. Combining multiple genes may create powerful prognostic biomarkers for respiratory diseases.
Area of Science:
- Pulmonology and Immunology
- Genetics and Biomarker Discovery
Background:
- Allergic rhinitis and asthma require early diagnosis and monitoring, driving biomarker research.
- Despite numerous gene discoveries, prognostic biomarkers for these conditions are not yet clinically applied.
- Current research focuses on identifying and categorizing potential biomarkers for improved patient outcomes.
Purpose of the Study:
- To systematically review and categorize over 161 potential biomarkers for allergic rhinitis and asthma.
- To explore the potential of combining multiple genes to develop prognostic biomarkers.
- To identify easily sampled, epithelium-derived biomarkers for innovative diagnostic panels.
Main Methods:
- Literature review and systematic categorization of genes and biomarkers.
- Grouping biomarkers based on origin (epithelial, infiltrate-derived, mixed) and cell-type specificity.
- Analysis of biomarkers associated with T-cell phenotypes (Th1, Th2, Th9, Th17, Th22, Tregs) and asthma endotypes.
Main Results:
- Over 161 potential biomarkers for respiratory inflammation were identified and categorized.
- Epithelium-derived biomarkers, such as CCL-26 and osteopontin, are key for classifying eosinophilic and neutrophilic asthma.
- Approximately 20 epithelium-derived biomarkers show promise for novel biomarker panels due to ease of sampling.
Conclusions:
- Combining multiple genes holds potential for creating novel prognostic biomarkers for allergic rhinitis and asthma.
- Epithelium-derived biomarkers offer a promising avenue for developing practical and effective diagnostic classifiers.
- Further research into these categorized biomarkers could significantly advance clinical management of allergic respiratory diseases.
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