Aging Biology in the Kidney

Related Experiment Video

Updated: Mar 28, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
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Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

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Markus Bitzer1, Jocelyn Wiggins1

  • 1Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; and Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Advances in Chronic Kidney Disease
|December 29, 2015
PubMed

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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