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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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In Vitro Drug Dissolution: Compendial Testing Models II01:09

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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In situ Grazing Incidence Small Angle X-ray Scattering on Roll-To-Roll Coating of Organic Solar Cells with Laboratory X-ray Instrumentation
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Analysis of large-scale tablet coating: Modeling, simulation and experiments.

P Boehling1, G Toschkoff1, K Knop2

  • 1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|December 29, 2015
PubMed
Summary
This summary is machine-generated.

This study optimized industrial tablet coating by simulating drum coating parameters. Decreasing spray rate and increasing nozzles significantly improved coating uniformity, crucial for pharmaceutical manufacturing.

Keywords:
DEMGPU simulationIndustrial scale simulationTablet coating

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Area of Science:

  • Chemical Engineering
  • Pharmaceutical Technology
  • Computational Fluid Dynamics

Background:

  • Tablet coating is critical for drug delivery and stability.
  • Optimizing industrial coating processes requires understanding complex parameter interactions.
  • Accurate simulation of large-scale coating is essential for process development.

Purpose of the Study:

  • To investigate the influence of key process parameters on tablet coating uniformity using simulation.
  • To validate the accuracy of Discrete Element Method (DEM) simulations for industrial-scale tablet coating.
  • To determine optimal parameters for achieving consistent inter-tablet coating variation.

Main Methods:

  • Full-scale Design of Simulation Experiment (DoSE) using Discrete Element Method (DEM).
  • Modeling tablets using the glued sphere approach (eight spheres per tablet).
  • Simulation of industrial drum coater using the eXtended Particle System (XPS).

Main Results:

  • The number of nozzles and spray rate significantly impacted the coefficient of inter-tablet coating variation (cv,inter).
  • Increased drum load and rotation rate enhanced tablet velocity but did not substantially affect cv,inter or process time.
  • Simulated process time for uniform coating correlated well with experimental data.

Conclusions:

  • DEM simulations accurately predict industrial-scale tablet coating performance.
  • Optimizing spray rate and nozzle number is key to minimizing coating variation.
  • The simulation approach provides valuable insights for efficient pharmaceutical coating process design.