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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

4.2K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.2K

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Related Experiment Video

Updated: Mar 28, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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Future Perspectives in Bladder Tissue Engineering.

Bradley C Gill1, Margot S Damaser2, Christopher J Chermansky3

  • 1Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic ; Lerner College of Medicine, Education Institute, Cleveland Clinic ; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.

Current Bladder Dysfunction Reports
|December 29, 2015
PubMed
Summary
This summary is machine-generated.

Tissue engineering aims to create better bladder tissues for patients. Current methods face challenges with vascularity and tissue ingrowth in larger grafts, limiting clinical success.

Keywords:
Autologous GraftRegenerative UrologyStem CellsTissue EngineeringUrinary Bladder

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Urology

Background:

  • Clinical need for improved urinary bladder augmentation/replacement persists.
  • Tissue engineering strategies are being explored for bladder reconstruction.
  • Existing approaches using scaffolds and cellularized grafts face limitations.

Purpose of the Study:

  • To review recent advancements in bladder tissue engineering.
  • To highlight challenges hindering clinical implementation of engineered bladder tissues.
  • To discuss strategies for improving scaffold vascularity and tissue integration.

Main Methods:

  • Review of current literature on bladder tissue engineering techniques.
  • Analysis of challenges related to graft vascularity and tissue ingrowth.
  • Discussion of novel scaffold development and cellularization methods.

Main Results:

  • Insufficient vascularity in large grafts limits tissue ingrowth and causes ischemia.
  • Scaffold design and in vitro cellularization are key areas of focus.
  • Recent research aims to enhance scaffold vascularity and promote tissue integration.

Conclusions:

  • Significant challenges remain in achieving sufficient vascularity for large engineered bladder grafts.
  • Further research is needed to overcome limitations in tissue ingrowth and central graft ischemia.
  • Optimizing scaffold properties and cellularization techniques is crucial for clinical translation.