Related Experiment Video
Updated: Mar 28, 2026
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
[Modified Mohs micrographic surgery in the treatment of cutaneous melanoma]
Qianxi Li1, Hang Li2, Ping Tu1
1Department of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China.
Objective:
To study the significance of modified Mohs micrographic surgery in the treatment of cutaneous melanoma with the most appropriate margins.
Methods:
A total of 20 cases with cutaneous melanoma treated by the technique of modified Mohs micrographic surgery from July 2013 to July 2014 were reviewed. Modified Mohs micrographic surgery set safe margin according to Guideline of Chinese Melanoma Treatment (2011) first, and then decide whether to adopt wider margins according to the pathology of the resected margin. Data concerning the numbers of additional resection and the final total width of margins were analyzed and the latter compared with the initial margins.
Results:
Among 20 cases, 7 cases (35%) needed more than two resections to obtain a clear margin. The final widths of margin in 7 cases (35%) are different from the guideline.
Conclusions:
Modified Mohs micrographic surgery could ensure the thorough removal of primary tumor, while avoiding residual tumor as well as over-excision, which reflect the trend toward individualized treatment and minimally traumatic surgery.
