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The frequency of HLA alleles in the Romanian population

Ileana Constantinescu1,2, Voicu Boșcaiu3, Petru Cianga4

  • 1Department of Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. ileana.constantinescu@imunogenetica.ro.

Immunogenetics
|December 30, 2015
PubMed

Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for bone marrow and kidney donor searches. The Romanian Caucasian population is heterogeneous and information on HLA polymorphism has not been well studied. We characterized the HLA genetic profile and allele frequencies of regional populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 individuals, belonging to the four main regions of Romania. The most common alleles found in the Romanian population are the following: HLA-A*01, A*02, A*03, A*11, A*24; HLA-B*18, B*35, B*44, B*51 and HLA-DRB1*01, DRB1*03, DRB1*07, DRB1*11, DRB1*13, DRB1*15, DRB1*16. More than half of the alleles are non-homogeneously spread in Romania. These results provide a starting point for future analyses of genetic heterogeneity in Romania.

Keywords:
Allele frequencyHLA polymorphismHuman leukocyte antigen (HLA)Population studies

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