Related Experiment Video
Updated: Mar 28, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Carbapenem-Resistant Enterobacteriaceae Infections in Children
Kathleen Chiotos1,2,3, Jennifer H Han4,5,6, Pranita D Tamma7
1Division of Critical Care, Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. chiotosk@email.chop.edu.
Abstract:
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the USA and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE are now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Bacterial Gastroenteritis
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Mechanism of Antibiotic Resistance in MRSA
Pharmacokinetics in Pediatric Patients: Drug Distribution

