Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antimicrobial agents in pediatrics.

M M Mustafa¹, G H McCracken

¹Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas.

Infectious Disease Clinics of North America

|September 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emotional intelligence and perceived stress among female dental students at King Khalid University, Saudi Arabia.

Nigerian journal of clinical practice·2021

Same author

Correction to 'On the computation of hybrid modes in planar layered waveguides with multiple anisotropic conductive sheets'.

Proceedings. Mathematical, physical, and engineering sciences·2019

Same author

Hemophagocytic syndrome.

Saudi medical journal·2016

Same author

Anterior poliomyelitis; from a patient's point of view.

Physiotherapy·2010

Same author

Tigecycline therapy significantly reduces the concentrations of inflammatory pulmonary cytokines and chemokines in a murine model of Mycoplasma pneumoniae pneumonia.

Antimicrobial agents and chemotherapy·2009

Same author

Acute aseptic meningitis associated with administration of immunoglobulin in children: A case report and review of the literature.

Annals of Saudi medicine·2007

Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026

Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026

Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026

Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026

Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026

Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026

See all related articles

Proper antimicrobial use in children requires understanding pharmacokinetics and host factors to avoid treatment failure or adverse effects. This review covers antibiotic pharmacokinetics and beta-lactam use in pediatric patients.

Area of Science:

Pediatric Pharmacology
Antimicrobial Stewardship

Background:

Antimicrobial agents require careful dosing in pediatric populations.
Neonatal and pediatric pharmacokinetics differ significantly from adults.
Inadequate understanding can lead to therapeutic failure or toxicity.

Purpose of the Study:

To review pharmacokinetic considerations for antimicrobials in infants and children.
To discuss clinical pharmacology and indications for beta-lactam antibiotics in pediatric patients.

Main Methods:

Review of pharmacokinetic principles in pediatric populations.
Analysis of clinical data on beta-lactam antibiotic use.
Synthesis of current guidelines and literature.

Main Results:

Related Experiment Videos

Pharmacokinetic variability in neonates and children necessitates age-specific dosing.
Beta-lactam antibiotics are crucial but require careful selection and monitoring.
Host factors (gestational/chronological age) significantly impact drug disposition.

Conclusions:

Optimizing antimicrobial therapy in children depends on understanding age-related pharmacokinetics.
Appropriate use of beta-lactam antibiotics is essential for effective pediatric treatment.
Further research into pediatric antimicrobial pharmacokinetics is warranted.