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Antibiotic use in the elderly. A selective review.

R A Gleckman1

  • 1University of Massachusetts Medical School, Worcester.

Infectious Disease Clinics of North America
|September 1, 1989
PubMed
Summary

Prescribing antibiotics to elderly patients presents unique challenges due to physiological changes and potential drug interactions. Careful consideration is needed to ensure safe and effective antibiotic therapy in this population.

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Infectious Disease

Background:

  • Advanced age is linked to physiological changes affecting drug metabolism and excretion.
  • Elderly patients often have comorbidities that complicate treatment.
  • Impaired cognitive and physical function can affect medication adherence.

Purpose of the Study:

  • To highlight the unique challenges in prescribing antibiotics to elderly patients.
  • To emphasize the risks associated with antibiotic use in geriatrics.
  • To underscore the importance of optimizing antibiotic therapy for older adults.

Main Methods:

  • Literature review on geriatric pharmacology and antibiotic use.
  • Analysis of physiological changes in aging relevant to drug disposition.
  • Examination of factors influencing drug compliance in the elderly.

Main Results:

  • Reduced drug excretion in the elderly increases the risk of adverse events.
  • Comorbidities and polypharmacy heighten the potential for drug interactions.
  • Cognitive and functional impairments challenge unsupervised medication management.

Conclusions:

  • Antibiotic prescribing for elderly patients requires careful risk-benefit assessment.
  • Strategies to mitigate adverse events and drug interactions are crucial.
  • Ensuring safe and effective antibiotic therapy necessitates tailored approaches for geriatric patients.

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