Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Third generation cephalosporins.

G R Donowitz1

  • 1Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.

Infectious Disease Clinics of North America
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infections in the neutropenic patient--new views of an old problem.

Hematology. American Society of Hematology. Education Program·2001
Same author

Algorithm-based decision rules to safely reduce laboratory test ordering.

Studies in health technology and informatics·2001
Same author

Sparfloxacin versus cefaclor in the treatment of patients with community-acquired pneumonia: a randomized, double-masked, comparative, multicenter study.

Clinical therapeutics·1998
Same author

Fever in the compromised host.

Infectious disease clinics of North America·1996
Same author

Risk factors for infection of adult patients with cancer who have tunnelled central venous catheters.

Cancer·1995
Same author

Tissue-directed antibiotics and intracellular parasites: complex interaction of phagocytes, pathogens, and drugs.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Third generation cephalosporins offer enhanced potency and a broad spectrum for treating difficult gram-negative bacterial infections. These agents show excellent cerebrospinal fluid penetration and are safe for conditions like meningitis and nosocomial infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Microbiology

Background:

  • Third generation cephalosporins represent an advancement over earlier generations.
  • They exhibit improved potency, broader antibacterial spectrum, and favorable pharmacologic profiles.

Purpose of the Study:

  • To evaluate the efficacy and characteristics of third generation cephalosporins.
  • To highlight their utility in treating challenging bacterial infections.

Main Methods:

  • Review of pharmacological data and clinical studies on third generation cephalosporins.
  • Assessment of in vitro susceptibility patterns against key pathogens.

Main Results:

  • High susceptibility rates observed for E. coli, Klebsiella pneumoniae, and Proteus, including resistant strains.

Related Experiment Videos

  • Specific agents like ceftazidime are effective against Pseudomonas aeruginosa.
  • Excellent cerebrospinal fluid penetration demonstrated by cefotaxime, ceftazidime, ceftriaxone, and ceftizoxime.

    • Conclusions:

    • Third generation cephalosporins are valuable therapeutic options for difficult gram-negative infections.
    • Their safety profile is comparable to other beta-lactam antibiotics.
    • Key applications include meningitis, nosocomial infections, and Pseudomonas aeruginosa infections.