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Related Concept Videos

Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

893
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
893
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Related Experiment Video

Updated: Mar 28, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

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Esophageal tissue engineering: Current status and perspectives.

T Poghosyan1, J Catry2, M Luong-Nguyen2

  • 1Service de chirurgie digestive, oncologique et métabolique, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France; CIC de biothérapies, Inserm UMR 1160, institut universitaire d'hématologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Journal of Visceral Surgery
|December 30, 2015
PubMed
Summary
This summary is machine-generated.

Tissue engineering offers a promising alternative for esophageal replacement, utilizing cell-seeded matrices and mesenchymal stem cells. Future "intelligent matrices" aim for standardized regeneration without implantation, advancing clinical trials.

Keywords:
Absorbable scaffoldBioengineeringEsophagusTissue engineering

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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Related Experiment Videos

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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Gastroenterology

Background:

  • Classical esophageal replacement techniques have limitations.
  • Current tissue engineering approaches involve acellular matrices seeded with autologous cells.
  • Mesenchymal stem cells are being investigated for their regenerative potential.

Purpose of the Study:

  • To explore tissue engineering as an alternative to traditional esophageal replacement.
  • To highlight the role of mesenchymal stem cells in esophageal regeneration.
  • To discuss future directions in esophageal substitute development.

Main Methods:

  • Utilizing acellular matrices combined with autologous epithelial and muscle cells.
  • Investigating the properties of mesenchymal stem cells for tissue regeneration.
  • Developing acellular "intelligent matrices" for in vivo tissue remodeling.

Main Results:

  • Hybrid approaches using acellular matrices and autologous cells show success.
  • Mesenchymal stem cells offer differentiation, proangiogenic, and immunomodulatory benefits.
  • Current applications are limited to enlargement plasties with non-cellular matrices.

Conclusions:

  • Tissue engineering holds potential for esophageal replacement, moving beyond current limitations.
  • Future intelligent matrices may enable standardized regeneration without implantation.
  • Advancements in translational research and large animal studies are crucial for clinical trial authorization.