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Updated: Mar 28, 2026

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
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Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

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Antibody Recognition of Disordered Antigens

Christopher A MacRaild1, Jack S Richards2, Robin F Anders3

  • 1Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.

Structure (London, England : 1993)
|December 30, 2015
PubMed
Summary

Disordered proteins are key antigens in infectious diseases. Antibodies recognize disordered epitopes as effectively as ordered ones, with recognition affinity weakly dependent on disorder, challenging previous assumptions.

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