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Experimental maxillary sinus augmentation using a highly bioactive glass ceramic.

Rodrigo Ricci Vivan1, Carlos Eduardo Mecca2, Claudia Cristina Biguetti3

  • 1Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo - FOB/USP, Al. Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

Journal of Materials Science. Materials in Medicine
|December 30, 2015
PubMed
Summary
This summary is machine-generated.

This study compared a novel bioactive glass ceramic (Biosilicate®) with bovine hydroxyapatite (Bio-Oss®) for maxillary sinus augmentation in rabbits. Biosilicate® showed an unfavorable healing response, necessitating further research.

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Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Regenerative Medicine

Background:

  • Biomaterial physicochemical properties impact biological integration and host response.
  • Maxillary sinus augmentation is crucial for dental implant placement, requiring effective bone regeneration biomaterials.

Purpose of the Study:

  • To compare bone healing in maxillary sinus augmentation using a novel bioactive glass ceramic (Biosilicate®) versus bovine hydroxyapatite (Bio-Oss®).
  • To evaluate the influence of biomaterial type and autogenous bone graft on bone formation and inflammatory response.

Main Methods:

  • Bilateral maxillary sinus augmentation in rabbits using four groups: Bio-Oss® (BO), BO + autogenous graft (G), Biosilicate® (BS), and BS + G.
  • Analysis at 45 and 90 days via light microscopy, SEM, μCT, and immunohistochemistry for bone markers.

Main Results:

  • Biosilicate® exhibited a different degradation pattern and induced more intense chronic inflammation and foreign body reaction compared to Bio-Oss®.
  • Direct bone-biomaterial contact and positive osteopontin/osteocalcin labeling were observed for both materials.
  • Bone matrix mineralization was delayed with Biosilicate® but approached Bio-Oss® levels by 90 days.

Conclusions:

  • Biosilicate® demonstrated an unfavorable healing response in rabbit maxillary sinus augmentation, characterized by inflammation and delayed mineralization.
  • Further investigation is required to identify factors contributing to Biosilicate®'s suboptimal performance and to optimize its use in bone regeneration.