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Published on: February 16, 2018
Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented
Dario Perdicchia1, Michael S Christodoulou2, Gaia Fumagalli3
1Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy. dario.perdicchia@unimi.it.
Abstract:
2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.
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