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Preliminary fsLIBS study on bone tumors.

Ruby K Gill1, Zachary J Smith2, Ripul R Panchal3

  • 1Center for Biophotonics, University of California, Davis, 95616, USA ; Department of Biomedical Engineering, University of California, Davis, 95616, USA ; These authors contributed equally to this work.

Biomedical Optics Express
|December 30, 2015
PubMed
Summary

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Femtosecond Laser Induced Breakdown Spectroscopy (fsLIBS) can distinguish primary bone tumors from normal bone by analyzing magnesium and calcium levels. This technique offers real-time feedback for precise laser surgery, potentially reducing repeat surgeries for bone tumor removal.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Laser Spectroscopy

Background:

  • Femtosecond laser surgery offers precise tissue ablation.
  • Real-time feedback systems are crucial for preventing unintended tissue damage during surgery.
  • Accurate differentiation between cancerous and normal bone is vital for effective tumor removal.

Purpose of the Study:

  • To assess the efficacy of femtosecond Laser Induced Breakdown Spectroscopy (fsLIBS) in differentiating between normal and cancerous bone tissue.
  • To explore the potential of fsLIBS as an integrated feedback system for femtosecond laser surgery in oncology.
  • To investigate the spectral signatures of primary bone tumors, secondary bone tumors, and normal bone.

Main Methods:

  • fsLIBS analysis was performed on patient-derived primary bone tumors, secondary bone tumors, and matched normal bone samples.
Keywords:
(170.1020) Ablation of tissue(170.4730) Optical pathology(170.6510) Spectroscopy, tissue diagnostics(300.0300) Spectroscopy(300.6365) Spectroscopy, laser induced breakdown

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  • Spectral signatures were characterized by acquiring a minimum of 20 spectra per sample.
  • Tissue samples were sourced from the UC Davis Cancer Center Biorepository.

    • Main Results:

    • No significant spectral differences were observed between secondary bone tumors and normal bone, attributed to tissue heterogeneity.
    • A notable increase in the ratio of magnesium to calcium peak intensity was detected in primary bone tumor samples compared to normal bone.
    • fsLIBS demonstrated potential in identifying specific biomarkers for bone tumor characterization.

    Conclusions:

    • fsLIBS shows promise as a real-time feedback tool for femtosecond laser surgery in treating primary bone tumors.
    • The observed changes in magnesium-to-calcium ratios could serve as a diagnostic indicator for primary bone tumors.
    • Further research is warranted to refine fsLIBS for clinical application in bone cancer surgery.