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Related Experiment Videos

Compounding with Silicones.

Loyd V Allen

    International Journal of Pharmaceutical Compounding
    |December 31, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Silicones are versatile materials used in medicine and pharmaceuticals, from life-saving devices to skincare products. Their safety and unique properties like low reactivity and hydrophobicity support diverse applications.

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    Area of Science:

    • Materials Science
    • Pharmaceutical Science
    • Biomedical Engineering

    Background:

    • Methylchlorosilanes have been used since the 1940s for glassware treatment to prevent blood clotting.
    • Silicone use has expanded significantly in medical and pharmaceutical fields.
    • Silicones are found in critical medical devices like pacemakers and hydrocephalic shunts.

    Purpose of the Study:

    • To review the diverse applications of silicones in pharmaceutical and medical fields.
    • To highlight the beneficial properties of silicones that support their widespread use.
    • To discuss the safety and efficacy of silicones in various healthcare products and formulations.

    Main Methods:

    • Review of historical and current applications of silicones in medicine and pharmaceuticals.

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  • Analysis of silicone properties contributing to their biocompatibility and functionality.
  • Examination of silicone use as active ingredients, excipients, and surface treatments.

    • Main Results:

    • Silicones are integral to numerous life-saving devices and pharmaceutical formulations.
    • Approximately 60% of skincare products contain silicones, valued for their aesthetic feel.
    • Silicones' low reactivity, low surface energy, and hydrophobicity underpin their biocompatibility and utility.
    • Applications include lubricants, adhesives, antiflatulents, and surface treatments for parenteral packaging.

    Conclusions:

    • Silicones are safe and effective materials with a broad range of applications in healthcare.
    • Their unique physicochemical properties make them indispensable in modern medicine and pharmaceutical development.
    • Continued innovation is expected in silicone-based formulations and medical device technologies.