Putative hormone with anti-obesogenic and insulin-sensitizing effect

Area of Science:

• Endocrinology
• Metabolic Research
• Molecular Biology

Background:

• Bone morphogenetic protein-9 (BMP-9) demonstrates insulin-like effects on glucose regulation.
• Existing research suggests BMP-9 influences glucose metabolism in hepatocytes.

Discussion:

• BMP-9 shares signaling pathways with insulin and other BMPs, indicating potential hepatic functions.
• The hypothesis proposes BMP-9 as the hepatic insulin-sensitizing substance (HISS).

Key Insights:

• BMP-9 administration improves glycemia in diabetic mouse models.
• BMP-9 regulates glucose metabolism, reinforcing its role in hepatic insulin sensitivity.

Outlook:

• Further investigation into BMP-9's role as HISS is warranted.
• Understanding BMP-9's signaling could lead to new diabetes therapies.