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Dermatomyositis and malignancy.

J B Richardson1, J P Callen

  • 1Department of Medicine, University of Louisville School of Medicine, Kentucky.

The Medical Clinics of North America
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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Dermatomyositis likely increases cancer risk, with tumor types mirroring general populations. Malignancy can appear before, during, or after dermatomyositis diagnosis, potentially sharing immune-related causes.

Area of Science:

  • Rheumatology
  • Oncology
  • Dermatology

Background:

  • Dermatomyositis is an idiopathic inflammatory myopathy.
  • A potential association between dermatomyositis and malignancy has been long suspected.

Purpose of the Study:

  • To summarize the relationship between dermatomyositis and malignancy.
  • To guide the search for malignancy in dermatomyositis patients.

Main Methods:

  • Review of existing literature and clinical observations.
  • Analysis of tumor types and their incidence in dermatomyositis patients.

Main Results:

  • Dermatomyositis is probably associated with an increased incidence of malignancy.
  • Tumor types in dermatomyositis patients approximate general population frequencies.

Related Experiment Videos

  • Malignancy can precede, coincide with, or follow dermatomyositis diagnosis.
  • Conclusions:

    • Dermatomyositis and malignancy may share a common pathogenesis involving abnormal immune function.
    • Malignancy screening in dermatomyositis patients should be based on clinical findings and laboratory tests.
    • Treatment of associated malignancy may not always impact the course of dermatomyositis.