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Adverse effects of amiodarone. Pathogenesis, incidence and management
G V Naccarelli1, R L Rinkenberger, A H Dougherty
1Division of Cardiology, University of Texas Medical School, Houston.
Medical Toxicology and Adverse Drug Experience
|July 1, 1989
Abstract:
Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonary fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.