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Long-term medication persistence in stroke patients treated with intravenous thrombolysis

Maja Stefanovic Budimkic1, Tatjana Pekmezovic2, Ljiljana Beslac-Bumbasirevic3

  • 1Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.

Clinical Neurology and Neurosurgery
|December 31, 2015
PubMed

Insights

Stroke survivors receiving intravenous thrombolysis (IVT) showed better long-term medication persistence for secondary prevention. Higher medication adherence was linked to better functional outcomes post-stroke.

Area of Science:

  • Neurology
  • Pharmacology
  • Public Health

Background:

  • Long-term medication persistence is crucial for secondary stroke prevention.
  • Data on medication persistence in stroke survivors treated with intravenous thrombolysis (IVT) is limited.
  • Understanding medication adherence post-IVT is vital for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate long-term medication persistence in stroke patients treated with IVT.
  • To compare medication persistence between IVT-treated and non-IVT-treated stroke patients.
  • To identify factors associated with medication persistence after acute ischemic stroke.

Main Methods:

  • Retrospective observational study of 203 IVT-treated and 197 non-IVT-treated acute ischemic stroke patients.
  • Median follow-up period of 3 years (range 1-7 years).
  • Analysis of secondary stroke prevention medications including anti-thrombotics, anti-hypertensives, statins, and hypoglycemics.

Main Results:

  • IVT-treated patients demonstrated significantly higher medication persistence (88.7%) compared to non-IVT-treated patients (69.0%).
  • IVT was an independent predictor of medication persistence (OR=2.93, 95% CI=1.48-5.81).
  • Higher medication persistence correlated with favorable long-term functional outcomes in both IVT and non-IVT groups.

Conclusions:

  • Stroke patients treated with IVT exhibit superior long-term medication persistence.
  • Lower medication persistence is associated with greater post-stroke disability.
  • Improving medication adherence in stroke survivors, particularly those with disabilities, is essential for secondary prevention.
Abstract

Keywords:
Intravenous thrombolysisMedication persistenceStroke outcome

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