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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Rescuing failed oral implants via Wnt activation.

Xing Yin1,2, Jingtao Li1,2, Tao Chen1,2

  • 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Clinical Periodontology
|January 1, 2016
PubMed
Summary

A WNT3A protein therapeutic (L-WNT3A) successfully rescued failing dental implants with fibrous encapsulation by promoting significant peri-implant bone formation and osseointegration.

Keywords:
biomechanicsfibrosisfinite element analysisosseointegrationosteogenesis

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Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Oral surgery

Background:

  • Dental implant osseointegration is crucial but can fail due to fibrous encapsulation.
  • Current treatments for failed implants are limited, often requiring removal.

Purpose of the Study:

  • To investigate if a WNT protein therapeutic could rescue implants with established fibrous encapsulation.
  • To evaluate the potential of WNT3A protein to promote bone formation around failing implants.

Main Methods:

  • Titanium implants were placed in murine models with insufficient primary stability.
  • Fibrous encapsulation was induced, and then peri-implant injections of liposomal WNT3A (L-WNT3A) or control (L-PBS) were administered.
  • Histomorphometry and quantitative assays analyzed Wnt responsiveness, cell proliferation, and osteogenic protein expression.

Main Results:

  • L-WNT3A treatment significantly increased Wnt pathway activity, cell proliferation, and osteogenic marker expression.
  • A notable increase in peri-implant bone volume and bone-to-implant contact was observed in the L-WNT3A group.
  • Implants treated with L-WNT3A demonstrated improved osseointegration compared to controls.

Conclusions:

  • Liposomal WNT3A effectively induces peri-implant bone formation.
  • L-WNT3A offers a potential therapeutic strategy to rescue failing dental implants with fibrous encapsulation.